Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Nutrients

Pietro Putignano¹  Niccolò Miraglia²  Simone Perna³  Valentina Braschi⁴  Mara Nichetti⁴  MilenaAnna Faliva⁴  Maurizio Naso⁴  Clara Gasparri⁴  Gabriella Peroni⁴  Daniele Spadaccini⁴  Giancarlo Iannello⁵  Mariangela Rondanelli⁶  TariqA. Alalwan⁷ 

[1] Pre-clinical Development, Gnosis SpA, 20121 Milan, Italy;;Clinical &Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038, Bahrain;Endocrinology and Nutrition Unit, Azienda di Servizialla Persona ‘‘Istituto Santa Margherita’’, University of Pavia, 27100 Pavia, Italy;General Management, Azienda di Servizialla Persona Istituto Santa Margherita, 27100 Pavia, Italy;IRCCS Mondino Foundation, 27100 Pavia, Italy;SP Diabetic Outpatient Clinic, ASST Monza, 20900 Monza, Italy;

关键词: non-animal chondroitin sulfate;    knee osteoarthritis;    pain;    inflammation;    overweight;    obesity;   

DOI  :  10.3390/nu11092027

来源: DOAJ

【 摘 要 】

Osteoarthritis (OA) is the most common form of arthritis in the world and is characterized by pain, various disabilities and loss of quality of life. Chondroitin sulfate (CS) is recommended as first-line therapy. CS of non-animal origin is of great interest for safety and sustainability reasons. This study aims to investigate the anti-inflammatory effects, anti-pain and ability-enhancement of a short-term supplementation with non-animal CS in overweight subjects with OA. In a randomized, double-blind, placebo-controlled pilot study, 60 overweight adults with symptomatic OA were allocated to consume 600 mg of non-animal CS (n = 30) or a placebo (n = 30) daily for 12 consecutive weeks. The assessment of knee-pain, quality of life, related inflammation markers and body composition was performed at 0, 4 and 12 weeks. The Tegner Lysholm Knee Scoring (TLKS) scale of the experimental group showed a statistically significant increase (+10.64 points; confidence interval (95% confidence interval (CI) 5.57; 15.70; p < 0.01), while the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score decreased (−12.24 points; CI 95% −16.01; −8.38; p < 0.01). The results also showed a decrease in the C-reactive protein (CRP) level (−0.14 mg/dL, CI 95% −0.26; −0.04; p < 0.01) and erythrocyte sedimentation rate (ESR) level (−5.01 mm/h, CI 95% −9.18; −0.84, p < 0.01) as well as the visual analogue scale (VAS) score in both knees. In conclusion, this pilot study demonstrates the effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers.

【 授权许可】

Unknown