期刊论文详细信息
Cancers
Photodynamic Therapy Using Hippo Pathway Inhibitor Verteporfin: A Potential Dual Mechanistic Approach in Treatment of Soft Tissue Sarcomas
Fatima Toor1  JeffreyD. Rytlewski2  Benjamin Miller3  Keith Garcia4  Nicholas Scalora4  Munir Tanas4  Bryan Allen5  Mohammed Milhem6  Varun Monga6 
[1] Department of Electrical and Computer Engineering, University of Iowa Technology Institute, The University of Iowa, Iowa City, IA 52242, USA;Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA;Department of Orthopedic Surgery, University of Iowa, Iowa City, IA 52242, USA;Department of Pathology, University of Iowa, Iowa City, IA 52242, USA;Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA;Division of Hematology, Oncology, and Blood & Marrow Transplant, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA;
关键词: Hippo pathway;    soft tissue sarcoma;    verteporfin;    photodynamic therapy;    YAP/TAZ;   
DOI  :  10.3390/cancers13040675
来源: DOAJ
【 摘 要 】

Sarcoma is a widely varied and devastating oncological subtype, with overall five-year survival of 65% that drops to 16% with the presence of metastatic disease at diagnosis. Standard of care for localized sarcomas is predicated on local control with wide-local resection and radiation therapy, or, less commonly, chemotherapy, depending on tumor subtype. Verteporfin has the potential to be incorporated into this standard of care due to its unique molecular properties: inhibition of the upregulated Hippo pathway that frequently drives soft tissue sarcoma and photodynamic therapy-mediated necrosis due to oxidative damage. The initial anti-proliferative effect of verteporfin is mediated via binding and dissociation of YAP/TEAD proteins from the nucleus, ultimately leading to decreased cell proliferation as demonstrated in multiple in vitro studies. This effect has the potential to be compounded with use of photodynamic therapy to directly induce cellular necrosis with use of a clinical laser. Photodynamic therapy has been incorporated into multiple malignancies and has the potential to be incorporated into sarcoma treatment.

【 授权许可】

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