Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial

Archives of Academic Emergency Medicine

Hassan Barzegari¹  Majid Hajimohammadi¹  Mina Kadkhodazadeh¹  Hassan Motamed¹  Behrad Ziapour¹ 

[1] Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.;

关键词: Pain management;    tension-type Headache;    administration;    intranasal;    lidocaine;    migraine disorders;   

DOI  :  10.22037/aaem.v5i1.204

来源: DOAJ

【 摘 要 】

Introduction: Most of the headache cases only require pain management in emergency department (ED). The present study aimed to evaluate the efficacy of intranasal lidocaine in this regard. Method: In this clinical trial, adult patients with primary headache were randomly treated with 7.5 mg intravenous (IV) chlorpromazine and 1 ml intranasal lidocaine 2% (treatment) or normal saline 0.9% (placebo), and were compared 5, 15, and 30 minutes later regarding success rate using SPSS 21. Result: 100 patients were assigned to either treatment or placebo group. Number needed to treat of intranasal lidocaine at 5, 15, and 30 minutes were 4 (95% CI: 2.2 – 6.6), 3 (95% CI: 1.7 – 3.5), and 4 (95% CI: 2.3 – 15.9), respectively. These measures for absolute risk reduction were 30 (95% CI: 15.2 – 44.8), 44 (95% CI: 28.7 – 59.3), and 26 percent (95% CI: 6.3 – 44.3), respectively. Pain relapse occurred in 16% of treatment and 11% of control group within 1 hour of treatment (p = 0.402). Conclusion: It seems that, intranasal lidocaine along with IV chlorpromazine could result in more successful and faster management of primary headaches in ED.

【 授权许可】

Unknown