The homogeneous and heterogeneous risk factors for the morbidity and prognosis of bone metastasis in patients with prostate cancer

Cancer Management and Research

关键词: bone metastases;    initial prostate cancer;    survival;    risk factor;   

DOI  :  

来源: DOAJ

【 摘 要 】

Xu Guo,1,2,* Chao Zhang,1,* Qi Guo,1,3,* Yao Xu,1 Guowei Feng,4 Lili Li,1 Xiuxin Han,1 Feng Lu,1 Yulin Ma,1 Xin Wang,5 Guowen Wang1 1Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, China; 2Department of Orthopedics, Cangzhou Central Hospital, Cangzhou, Hebei, China; 3Department of Orthopedics, General Hospital of North China Petroleum Administration, Renqiu, Hebei, China; 4Department of Urology, Tianjin Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; 5Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, Chongqing, China *These authors contributed equally to this work Purpose: Using the Surveillance, Epidemiology, and End Results database (SEER) to assess the incidence and risk factors of morbidity and prognosis for bone metastases in initial metastatic prostate cancer.Patients and methods: The records of 249,331 prostate cancer patients in the SEER database, diagnosed between 2010 and 2014, were obtained were obtained to investigate the risk factors for developing bone metastasis, and the records of 9925 of them who registered before 2013 were retrieved (with at least 1 year follow up) to explore the prognostic factors for bone metastasis. Multivariate logistic and Cox regression were used to identify risk factors and prognostic factors for bone metastases, respectively.Results: In total, 12,794 patients (5.1%) were diagnosed with bone metastases at the initial diagnosis. Older age, unmarried status, lymph node metastasis, poor tumor differentiation grade (Gleason grade), metastases at lung, brain, and liver were all positively associated with risk for the morbidity and prognosis of bone metastasis in prostate cancer. Black race and higher T stage were positively associated with bone metastasis development; however, they were not associated with a prognosis of bone metastasis.Conclusion: The incidence of bone metastasis in prostate cancer was approximately 5% with poor survival. The prostate cancer has homogeneous and heterogeneous risk factors for incidence and prognosis of bone metastasis, which may provide potential guidelines for the screening and preventive treatment for the bone metastasis of prostate cancer. Keywords: bone metastases, initial prostate cancer, survival, risk factor 

【 授权许可】

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