Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis

Učenye Zapiski Sankt-Peterburgskogo Gosudarstvennogo Medicinskogo Universiteta im. Akad. I.P. Pavlova

O. A. Berkovich¹  E. I. Baranova¹  E. G. Sergeeva¹  Z. I. Ionova¹  S. N. Pchelina¹ 

[1] Pavlov First Saint Petersburg State Medical University;

关键词: рецепторы активатора пролиферации пероксисом;    ppar;    тиазолидиндионы;    фибраты;    омега-3 пнжк;    статины;    алеглитазар;   

DOI  :  10.24884/1607-4181-2016-23-2-15-20

来源: DOAJ

【 摘 要 】

Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis.

【 授权许可】

Unknown