Učenye Zapiski Sankt-Peterburgskogo Gosudarstvennogo Medicinskogo Universiteta im. Akad. I.P. Pavlova | |
Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis | |
O. A. Berkovich1  E. I. Baranova1  E. G. Sergeeva1  Z. I. Ionova1  S. N. Pchelina1  | |
[1] Pavlov First Saint Petersburg State Medical University; | |
关键词: рецепторы активатора пролиферации пероксисом; ppar; тиазолидиндионы; фибраты; омега-3 пнжк; статины; алеглитазар; | |
DOI : 10.24884/1607-4181-2016-23-2-15-20 | |
来源: DOAJ |
【 摘 要 】
Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis.
【 授权许可】
Unknown