Antibacterials in Aquatic Environment and Their Toxicity to Fish

Pharmaceuticals

Bartosz Bojarski¹  Barbara Kot²  Małgorzata Witeska² 

[1] Department of Zoology and Animal Welfare, Faculty of Animal Science, University of Agriculture in Krakow, Mickiewicza 24/28, 30-059 Krakow, Poland;Institute of Biological Sciences, Faculty of Exact and Natural Sciences, Siedlce University of Natural Sciences and Humanities, Prusa 14, 08-110 Siedlce, Poland;

关键词: antibiotics;    chemotherapeutics;    toxic effects;    oxidative stress;    hematological changes;    histopathology;   

DOI  :  10.3390/ph13080189

来源: DOAJ

【 摘 要 】

Antibacterial agents are commonly present in aquatic environment at low concentrations. Terrestrial animal farms, human medicine and aquaculture are main sources of water contamination with antibacterials. Antibiotics were proved to be directly toxic to fish causing oxidative stress, general stress response, histopathological lesions, hematological, metabolic, and reproductive disorders, as well as immunosuppressive and genotoxic effects. Environmentally realistic low concentrations of antibiotics also disturb aquatic bacterial communities causing alterations in fish symbiotic microbiota and induce emergence of antibiotic-resistant pathogenic bacteria by exerting selective pressure on spread of antibiotic-resistance genes.

【 授权许可】

Unknown