Purinergic Regulation of Endothelial Barrier Function

International Journal of Molecular Sciences

Muhammad Aslam¹  Dursun Gündüz¹  Christian Troidl¹  ChristianW. Hamm¹  Jacqueline Heger²  Rainer Schulz² 

[1] Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany;Institute of Physiology, Justus Liebig University, 35392 Giessen, Germany;

关键词: Rac1;    RhoA;    peripheral actin;    adenosine;    ATP;    ADP;   

DOI  :  10.3390/ijms22031207

来源: DOAJ

【 摘 要 】

Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5′-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions.

【 授权许可】

Unknown