New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

Frontiers in Pharmacology

George Bayliss¹  Shougang Zhuang²  Chaoyang Ye³  Minghai Shao³ 

[1] Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United States;Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

关键词: renal fibrosis;    Chinese herbs;    monomers;    chronic kidney disease;    Abelmoschus manihot;    Salvia miltiorrhiza;   

DOI  :  10.3389/fphar.2021.774414

来源: DOAJ

【 摘 要 】

The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.

【 授权许可】

Unknown