Bifidobacterial Transfer from Mother to Child as Examined by an Animal Model

Microorganisms

Marco Ventura¹  Giulia Longhi²  Rosaria Anzalone²  Francesca Turroni³  Sabrina Duranti³  Christian Milani³  Walter Mancino³  Leonardo Mancabelli³  GabrieleAndrea Lugli³  Douwe van Sinderen⁴  Andrea Sgoifo⁵  Luca Carnevali⁵  Rosario Statello⁵ 

[1] APC Microbiome Institute, University College Cork, T12 YT20 Cork, Ireland;GenProbio srl, 43124 Parma, Italy;Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy;;School of Microbiology &Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy;

关键词: bifidobacteria;    infant gut microbiota;    microbe-host coevolution;    metagenomics;   

DOI  :  10.3390/microorganisms7090293

来源: DOAJ

【 摘 要 】

Bifidobacteria commonly constitute the most abundant group of microorganisms in the healthy infant gut. Their intestinal establishment is believed to be maternally driven, and their acquisition has even been postulated to occur during pregnancy. In the current study, we evaluated bifidobacterial mother-to infant transmission events in a rat model by means of quantitative PCR (qPCR), as well as by Internally Transcribed Spacer (ITS) bifidobacterial profiling. The occurrence of strains supplied by mothers during pregnancy to their corresponding newborns was observed and identified by analysis immediately following C-section delivery. These findings provide intriguing support for the existence of an unknown route to facilitate bifidobacterial transfer during the very early stages of life.

【 授权许可】

Unknown