Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases

Frontiers in Cell and Developmental Biology

Xue-Qiang Wang¹  Xuan Su²  Zheng Yang²  Pei-Jie Chen²  Ge Song²  Yi-Li Zheng²  Yu-Meng Chen²  Jia-Bao Guo³ 

[1] Department of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, China;Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China;The Second School of Clinical Medicine, Xuzhou Medical University, Xuzhou, China;

关键词: degenerative musculoskeletal disorders;    aging;    age-related disease;    non-coding RNAs;    miRNA;    circRNA;   

DOI  :  10.3389/fcell.2021.753931

来源: DOAJ

【 摘 要 】

Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD.

【 授权许可】

Unknown