Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

Journal of Functional Biomaterials

OrtensiaIlaria Parisi¹  Luca Scrivano¹  Mariarosa Ruffo¹  Francesco Puoci¹  Vincenzo Pezzi¹  Rocco Malivindi¹  Fabio Amone²  AnnaFrancesca Vattimo² 

[1] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy;Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende (CS), Italy;

关键词: hair loss;    androgenetic alopecia (AGA);    5α-reductase;    polymeric blend;    hyaluronic acid;    soybean proteins;    Origanum vulgare leaf extract;    Camellia Sinensis leaf extract;    Capsicum Annuum fruit extract;    EPISKIN model;   

DOI  :  10.3390/jfb9030044

来源: DOAJ

【 摘 要 】

Hair loss represents a condition that adversely affects the social life of patients. The most common cause is androgenetic alopecia (AGA), which is a genetically determined progressive hair-loss condition involving 5α-reductase. In this study, a novel anti-baldness agent based on Interconnected PolymerS TeChnology (IPSTiC), which is an effective strategy for the delivery of bioactive molecules, was developed. This product (IPSTiC patch hair) is based on a polymeric blend consisting of high molecular weight hyaluronic acid and soybean proteins and is able to improve efficacy and stability of bioactive ingredients such as Origanum vulgare leaf extract, Camellia Sinensis leaf extract, and Capsicum Annuum fruit extract. The efficacy of the developed anti-baldness agent was investigated by performing several tests including NO radical and 5α-reductase inhibition assays, stability studies under different conditions, and in vitro diffusion studies using Franz cells. The biocompatibility of IPSTiC patch hair was also evaluated by in vitro analysis of the pro-sensitising potential and EPISKIN model. The obtained results confirmed both the efficacy and safety of IPSTiC patch hair supporting the potential use of this product in the topical treatment of AGA.

【 授权许可】

Unknown