Revista da Sociedade Brasileira de Medicina Tropical | |
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil | |
关键词: Chagas disease; Benznidazole; Drug-related side effects; Adverse reactions; | |
DOI : 10.1590/0037-8682-0150-2019 | |
来源: DOAJ |
【 摘 要 】
AbstractINTRODUCTION:Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District.METHODS:Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality.RESULTS:Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%).CONCLUSIONS:The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.
【 授权许可】
Unknown