Immune Responses to Pseudomonas aeruginosa Biofilm Infections

Frontiers in Immunology

Tim Tolker-Nielsen¹  Peter Østrup Jensen¹  Morten Rybtke¹  Kim Thomsen²  Claus Moser²  Mette Kolpen²  Anne Sofie Lauland²  Hannah Trøstrup³ 

[1] Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark;

关键词: biofilm infections;    Pseudomonas aeruginosa;    innate immune response;    adaptive immune response;    novel treatment possibilities;   

DOI  :  10.3389/fimmu.2021.625597

来源: DOAJ

【 摘 要 】

Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these infections the bacteria congregate in biofilms and cannot be eradicated by standard antibiotic treatment or host immune responses. The persistent biofilms induce a hyper inflammatory state that results in collateral damage of the adjacent host tissue. The host fails to eradicate the biofilm infection, resulting in hindered remodeling and healing. In the present review we describe our current understanding of innate and adaptive immune responses elicited by P. aeruginosa biofilms in cystic fibrosis lung infections and chronic wounds. This includes the mechanisms that are involved in the activation of the immune responses, as well as the effector functions, the antimicrobial components and the associated tissue destruction. The mechanisms by which the biofilms evade immune responses, and potential treatment targets of the immune response are also discussed.

【 授权许可】

Unknown