Repetitive anodal transcranial direct current stimulation improves neurological outcome and survival in a ventricular fibrillation cardiac arrest rat model

Brain Stimulation

Juan Wang¹  Changlin Yin¹  Yuanyuan Huang²  Yongqin Li³  Gang Chen³  Jianjie Wang³  Yushun Gong³  Chenxi Dai³  Bihua Chen³  Liang Wei³ 

[1] Department of Emergency, Southwest Hospital, Army Medical University, Chongqing, China;Department of Neurology, Southwest Hospital, Army Medical University, Chongqing, China;School of Biomedical Engineering and Imaging Medicine, Army Medical University, Chongqing, China;

关键词: Cardiac arrest;    Neurological outcome;    Survival;    Targeted temperature management;    Transcranial direct current stimulation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Transcranial direct current stimulation (tDCS) modulates neuronal activity and is a potential therapeutic tool for many neurological diseases. However, its beneficial effects on post cardiac arrest syndrome remains uncertain. Objective/hypothesis: We investigated the effects of repetitive anodal tDCS on neurological outcome and survival in a ventricular fibrillation (VF) cardiac arrest rat model. Methods: Cardiopulmonary resuscitation was initiated after 6 min of VF in 36 Sprague-Dawley rats. The animals were randomized into three groups immediately after resuscitation (n = 12 each): no-treatment control (NTC) group, targeted temperature management (TTM) group, and tDCS group. For tDCS, 1 mA anodal tDCS was applied on the dorsal scalp for 0.5 h. The stimulation was repeated for four sessions with 1-h resting interval under normothermia. Post-resuscitation hemodynamic, cerebral, and myocardial injuries, 96-h neurological outcome, and survival were evaluated. Results: Compared with the NTC group, post-resuscitation serum astroglial protein S100 beta and cardiac troponin T levels and 96-h neuronal and myocardial damage scores were markedly reduced in the tDCS and TTM groups. Myocardial ejection fraction, neurological deficit score, and 96-h survival rate were also significantly better for the tDCS and TTM groups. The period of post-resuscitation arrhythmia with hemodynamic instability was considerably shorter in the tDCS group, but no differences were observed in neurological outcome and survival between the tDCS and TTM groups. Conclusions: In this cardiac arrest rat model, repeated anodal tDCS commenced after resuscitation improves 96-h neurological outcome and survival to an extent comparable to TTM by attenuating post-resuscitation cerebral and cardiac injuries.

【 授权许可】

Unknown