Endothelial-to-Mesenchymal Transition in Cancer

Frontiers in Cell and Developmental Biology

Nicolas Clere¹  Isabelle Corre²  Sarah Renault² 

[1] Micro and Nanomédecines Translationnelles, Université d’Angers, INSERM UMR U1066, CNRS 6021, Angers, France;Sarcomes Osseux et Remodelage des Tissus Calcifiés, Université de Nantes, INSERM UMR U1238, Nantes, France;

关键词: endothelial;    mesenchymal;    plasticity;    cancer;    CAF;    metastasis;   

DOI  :  10.3389/fcell.2020.00747

来源: DOAJ

【 摘 要 】

Cancer is one of the most important causes of morbidity and mortality worldwide. Tumor cells grow in a complex microenvironment constituted of immune, stromal, and vascular cells that supports growth, angiogenesis, and metastasis. Endothelial cells (ECs) are major components of the vascular microenvironment. These cells have been described for their plasticity and potential to transdifferentiate into mesenchymal cells through a process known as endothelial-to-mesenchymal transition (EndMT). This complex process is controlled by various factors, by which ECs convert into a phenotype characterized by mesenchymal protein expression and motile, contractile morphology. Initially described in normal heart development, EndMT is now identified in several pathologies, and especially in cancer. In this review, we highlight the process of EndMT in the context of cancer and we discuss it as an important adaptive process of the tumor microenvironment that favors tumor growth and dissemination but also resistance to treatment. Thus, we underline targeting of EndMT as a potential therapeutic strategy.

【 授权许可】

Unknown