Trends of HIV-Related Cancer Mortality between 2001 and 2018: An Observational Analysis

Tropical Medicine and Infectious Disease

Amr Radwan¹  Umit Tapan¹  Omar Al Omari²  Zuha Pandit²  Alexander Walker²  Chinmay Jani²  Justin D. Salciccioli³  Conor Crowley⁴  Joseph Shalhoub⁴  Kripa Patel⁴  Dominic C. Marshall⁴  Georgina Hanbury⁴  Richard Goodall⁴  Harpreet Singh⁴  Christian Mouchati⁴ 

[1] Department of Internal Medicine, Section of Hematology and Oncology, Boston Medical Center, Boston, MA 02118, USA;Department of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA 02138, USA;Harvard Medical School, Boston, MA 02115, USA;MDR Collaboration, London W2 1NY, UK;

关键词: HIV;    mortality;    WHO;    world;    cancer;    trend;   

DOI  :  10.3390/tropicalmed6040213

来源: DOAJ

【 摘 要 】

The burden of AIDS-defining cancers has remained relatively steady for the past two decades, whilst the burden of non-AIDS-defining cancer has increased. Here, we conduct a study to describe mortality trends attributed to HIV-associated cancers in 31 countries. We extracted HIV-related cancer mortality data from 2001 to 2018 from the World Health Organization Mortality Database. We computed age-standardized death rates (ASDRs) per 100,000 population using the World Standard Population. Data were visualized using Locally Weighted Scatterplot Smoothing (LOWESS). Data for females were available for 25 countries. Overall, there has been a decrease in mortality attributed to HIV-associated cancers among most of the countries. In total, 18 out of 31 countries (58.0%) and 14 out of 25 countries (56.0%) showed decreases in male and female mortality, respectively. An increasing mortality trend was observed in many developing countries, such as Malaysia and Thailand, and some developed countries, such as the United Kingdom. Malaysia had the greatest increase in male mortality (+495.0%), and Canada had the greatest decrease (−88.5%). Thailand had the greatest increase in female mortality (+540.0%), and Germany had the greatest decrease (−86.0%). At the endpoint year, South Africa had the highest ASDRs for both males (16.8/100,000) and females (19.2/100,000). The lowest was in Japan for males (0.07/100,000) and Egypt for females (0.028/100,000).

【 授权许可】

Unknown