The effect of electroconvulsive therapy on cerebral monoamine oxidase A expression in treatment-resistant depression investigated using positron emission tomography

Brain Stimulation

Richard Frey¹  Andreas Hahn²  Marcus Hacker³  Verena Pichler⁴  Chrysoula Vraka⁴  Theresa Balber⁴  Rupert Lanzenberger⁴  Wolfgang Wadsak⁴  Cécile Philippe⁴  Siegfried Kasper⁴  Jakob Unterholzner⁵  Gregor Gryglewski⁵  Gregory M. James⁵  Georg S. Kranz⁵  Pia Baldinger-Melich⁵  Leo Silberbauer⁵  Markus Mitterhauser⁵  Thomas Vanicek⁵  Dietmar Winkler⁵ 

[1] Center for Biomarker Research in Medicine (CBmed), Graz, Austria;Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong;Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria;Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Austria;Neuroimaging Labs (NIL) PET, MRI, EEG, TMS and Chemical Lab, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria;

关键词: Monoamine oxidase A;    Treatment-resistant depression;    Electroconvulsive therapy;    Positron emission tomography;    [11C]harmine;    Neuroimaging;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Electroconvulsive therapy (ECT) constitutes one of the most effective antidepressant treatment strategies in major depression (MDD). Despite its common use and uncontested efficacy, its mechanism of action is still insufficiently understood. Previously, we showed that ECT is accompanied by a global decrease of serotonin-1A receptors in MDD; however, further studies to investigate the involvement of the serotonergic system in the mechanism of action of ECT are warranted. The monoamine oxidase A (MAO-A) represents an important target for antidepressant treatments and was found to be increased in MDD. Here, we investigated whether ECT impacts on MAO-A levels in treatment-resistant patients (TRD). Methods: 16 TRD patients (12 female, age 45.94 ± 9.68 years, HAMD 25.12 ± 3.16) with unipolar depression according to DSM-IV were scanned twice before (PET1 and PET2, to assess test-retest variability under constant psychopharmacotherapy) and once after (PET3) completing a minimum of eight unilateral ECT sessions using positron emission tomography and the radioligand [11C]harmine to assess cerebral MAO-A distribution volumes (VT). Age- and sex-matched healthy subjects (HC) were measured once. Results: Response rate to ECT was 87.5%. MAO-A VT was found to be significantly reduced after ECT in TRD patients (−3.8%) when assessed in 27 a priori defined ROIs (p < 0.001). Test-retest variability between PET1 and PET2 was 3.1%. MAO-A VT did not significantly differ between TRD patients and HC at baseline. Conclusions: The small effect size of the significant reduction of MAO-A VT after ECT in the range of test-retest variability does not support the hypothesis of a clinically relevant mechanism of action of ECT based on MAO-A. Furthermore, in contrast to studies reporting elevated MAO-A VT in unmedicated depressed patients, MAO-A levels were found to be similar in TRD patients and HC which might be attributed to the continuous antidepressant pharmacotherapy in the present sample.

【 授权许可】

Unknown