Inflammation and cutaneous nervous system involvement in hypertrophic scarring

Neural Regeneration Research

关键词: nerve regeneration;    peripheral nerve regeneration;    hypertrophic scar;    interleukin-13;    wound healing;    nerve growth factor;    neural regeneration;   

DOI  :  10.4103/1673-5374.167769

来源: DOAJ

【 摘 要 】

This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.

【 授权许可】

Unknown