Emerging Roles for Immune Cells and MicroRNAs in Modulating the Response to Cardiac Injury

Journal of Cardiovascular Development and Disease

AdrianaM. Rodriguez¹  ViravuthP. Yin¹ 

[1] Kathryn W. Davis Center for Regenerative Biology and Medicine, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA;

关键词: myocardial infarction;    heart regeneration;    macrophages;    regulatory T cells;    microRNAs;    zebrafish;    cardiomyocyte proliferation;    fibrosis;   

DOI  :  10.3390/jcdd6010005

来源: DOAJ

【 摘 要 】

Stimulating cardiomyocyte regeneration after an acute injury remains the central goal in cardiovascular regenerative biology. While adult mammals respond to cardiac damage with deposition of rigid scar tissue, adult zebrafish and salamander unleash a regenerative program that culminates in new cardiomyocyte formation, resolution of scar tissue, and recovery of heart function. Recent studies have shown that immune cells are key to regulating pro-inflammatory and pro-regenerative signals that shift the injury microenvironment toward regeneration. Defining the genetic regulators that control the dynamic interplay between immune cells and injured cardiac tissue is crucial to decoding the endogenous mechanism of heart regeneration. In this review, we discuss our current understanding of the extent that macrophage and regulatory T cells influence cardiomyocyte proliferation and how microRNAs (miRNAs) regulate their activity in the injured heart.

【 授权许可】

Unknown