Utilizing Plant Synthetic Biology to Improve Human Health and Wellness

Frontiers in Plant Science

Benjamin J. Endelman¹  Collin R. Barnum¹  Patrick M. Shih⁵ 

[1]Department of Plant Biology, University of California, Davis, Davis, CA, United States

[2]Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, United States

[3]Feedstocks Division, Joint BioEnergy Institute, Emeryville, CA, United States

[4]Genome Center, University of California, Davis, Davis, CA, United States

[5]Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, United States

[6]Lawrence Berkeley National Laboratory, Environmental Genomics and Systems Biology Division, Berkeley, CA, United States

关键词: plant synthetic biology;    natural products;    nutraceuticals;    pharmaceuticals;    human health;    nutrition;   

DOI  :  10.3389/fpls.2021.691462

来源: DOAJ

【 摘 要 】

Plants offer a vast source of bioactive chemicals with the potential to improve human health through the prevention and treatment of disease. However, many potential therapeutics are produced in small amounts or in species that are difficult to cultivate. The rapidly evolving field of plant synthetic biology provides tools to capitalize on the inventive chemistry of plants by transferring metabolic pathways for therapeutics into far more tenable plants, increasing our ability to produce complex pharmaceuticals in well-studied plant systems. Plant synthetic biology also provides methods to enhance the ability to fortify crops with nutrients and nutraceuticals. In this review, we discuss (1) the potential of plant synthetic biology to improve human health by generating plants that produce pharmaceuticals, nutrients, and nutraceuticals and (2) the technological challenges hindering our ability to generate plants producing health-promoting small molecules.

【 授权许可】

Unknown