Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study

Bosnian Journal of Basic Medical Sciences

Atefeh Yazdi¹  Minoo Yaghmaie¹  Saeedeh Salimi²  Mojtaba Sajadian³  Abbas Mohammadpour-Gharehbagh⁴  Soodabeh Rezaee⁴  Maryam Khodamian⁵  Mojgan Mokhtari⁵ 

[1] School of Medicine, Zahedan University of Medical Sciences, Zahedan;Cellular and Molecular Research Center and Department of Clinical Biochemistry, School of Medicine,Zahedan University of Medical Sciences, Zahedan, Iran;Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;School of Medicine, Zahedan University of Medical Sciences, Zahedan;Zahedan University of Medical Sciences, Zahedan;

关键词: Cytochrome P450 1A1;    haplotype;    gene;    polymorphism;    uterine leiomyoma;   

DOI  :  10.17305/bjbms.2016.1245

来源: DOAJ

【 摘 要 】

Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 patients with UL and 112 healthy women as controls. Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene were analyzed by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods, respectively. The findings indicated no association between Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene and UL (p < 0.05). However, the combination effect of TT/AG genotypes of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms was associated with 4.3-fold higher risk of UL. In addition, haplotype analysis revealed that TG haplotype of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms could increase the UL risk nearly 4.9-fold. Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms of CYP1A1 gene were not associated with UL susceptibility; however, the combination of the TT/AG genotypes and TG haplotype could increase the UL risk.

【 授权许可】

Unknown