A nationwide multi-institutional retrospective study to identify prognostic factors and develop a graded prognostic assessment system for patients with brain metastases from uterine corpus and cervical cancer

BMC Cancer

On Behalf of the Committee of Brain Tumor Registry of Japan Supported by the Japan Neurosurgical Society¹  Fumi Higuchi²  Takeshi Okuda³  Keishi Makino⁴  Hideaki Takahashi⁵  Masatoshi Takagaki⁶  Yoshiko Okita⁷  Jiro Akimoto⁸  Yasuyuki Hirashima⁹  Yuzo Hasegawa^1,10  Masamichi Takahashi^1,11  Yoshitaka Narita^1,11  Koichi Mitsuya^1,12  Yoko Nakasu^1,12  Nakamasa Hayashi^1,12 

[1]

[2]Department of Neurosurgery, Dokkyo Medical University

[3]Department of Neurosurgery, Kinki University

[4]Department of Neurosurgery, Kumamoto University

[5]Department of Neurosurgery, Niigata Cancer Center Hospital

[6]Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular disease

[7]Department of Neurosurgery, Osaka National Hospital

[8]Department of Neurosurgery, Tokyo Medical University

[9]Division of Gynecology, Shizuoka Cancer Center Hospital

[10]Division of Neurological Surgery, Chiba Cancer Center

[11]Division of Neurosurgery, National Cancer Center

[12]Division of Neurosurgery, Shizuoka Cancer Center Hospital

关键词: Brain metastasis;    Graded prognostic assessment;    Radiation;    Surgery;    Uterine cervical cancer;    Uterine corpus cancer;   

DOI  :  10.1186/s12885-017-3358-6

来源: DOAJ

【 摘 要 】

Abstract Background The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved local control as a result of new effective treatments. However, little information is available regarding their clinical characteristics and prognosis, because oncologists have encountered BM from uterine cancer on rare occasions. Methods Records from 81 patients with uterine BM were collected from 10 institutes in Japan. These were used in a multi-institutional study to identify prognostic factors and develop a graded prognostic assessment (GPA) for patients with BM from uterine cancer. Results Median OS after the development of BM was 7 months (95% confidence interval, 4 to 10 months). Multivariate analysis revealed that there were survival differences according to the existence of extracranial metastases and number of BM. In the present uterine-GPA, a score of 0 was assigned to those patients with ≥5 BM and extracranial metastasis, a score of 2 was assigned to those patients with one to four BM or without extracranial metastasis, and a score of 4 was assigned to those patients with one to four BM and without extracranial metastasis. The median OS for patients with a uterine-GPA scores of 0, 2, and 4 was 3, 7, and 22 months, respectively. A survival analysis confirmed the presence of statistically significant differences between these groups (p < 0.05). The results were validated by data obtained from the National Report of Brain Tumor Registry of Japan. Conclusion Uterine GPA incorporates two simple clinical parameters of high prognostic significance and can be used to predict the expected survival times in patients with BM from uterine cancer. Its use may help in determining an appropriate treatment for individual patients with BM.

【 授权许可】

Unknown