Recent advances in understanding and managing hairy cell leukemia [version 1; referees: 4 approved]

F1000Research

Tobias Roider¹  Sascha Dietrich¹  Brunangelo Falini² 

[1]Department of Medicine V, University of Heidelberg, Heidelberg, Germany

[2]Institute of Hematology and Center for Hemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy

DOI  :  10.12688/f1000research.13265.1

来源: DOAJ

【 摘 要 】

Hairy cell leukemia is a rare B-cell malignancy that is characterized by an indolent course. It was initially described as a distinct entity in 1958. Before the establishment of modern treatment, median survival was only 4 years. Since then, major advances in the treatment and understanding of the biology and genomic landscape of hairy cell leukemia have been made. This review summarizes the present understanding of hairy cell leukemia with particular focus on the development of novel and targeted approaches to treatment.

【 授权许可】

Unknown