Epigenetic Priming in Childhood Acute Lymphoblastic Leukemia

Frontiers in Cell and Developmental Biology

Marta Isidro-Hernández²  Ana Casado-García²  Carolina Vicente-Dueñas²  Javier Raboso-Gallego² 

[1] Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Salamanca, Spain;Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain;

关键词: epigenetic priming;    reprogramming;    childhood leukemia;    B-ALL;    T-ALL;    stem cells;   

DOI  :  10.3389/fcell.2019.00137

来源: DOAJ

【 摘 要 】

Leukemogenesis is considered to be a process by which a normal cell acquires new but aberrant identity in order to disseminate a malignant clonal population. Under this setting, the phenotype of the leukemic cells is identical to the leukemia-initiating cell in which the genetic insult is taking place. Thus, with some exceptions, B-cell and T-cell childhood leukemias are supposed to arise from B- or T-committed cells. In contrast, several recent studies have revealed that genetic alterations may act in a “hit-and-run” way in the cell-of-origin by imposing the tumor cell identity giving rise to either B-cell or T-cell leukemias. This novel mechanism of cell transformation is mediated by an epigenetic priming mechanism that is established by the initial genetic lesion. This initial hit might be unnecessary for the subsequent tumor evolution and conservation, being the epigenetic priming the engine for the tumor evolution.

【 授权许可】

Unknown