Performance and acceptability of self-collected human papillomavirus testing among women living with HIV

International Journal of Infectious Diseases

Kristen Lee¹  Jean Keller²  Runzhi Wang²  Jenell Coleman²  Charlotte A. Gaydos³  Jean Anderson⁴ 

[1] Corresponding author at: Johns Hopkins School of Medicine, 600 North Wolfe Street, Phipps Building Room 248, Baltimore, MD 21287, USA.;Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;Department of Medicine, Infectious Disease Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA;

关键词: Self-collection;    HPV testing;    Cervical cancer screening;    Women living with HIV;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: To assess the validity, reliability, and acceptability of self-collected human papillomavirus (HPV) tests in women living with HIV (WLHIV) in the United States. Methods: WLHIV ≥30 years of age underwent self-collected (clinic and home) and clinician-collected HPV tests. Sensitivity and specificity analyses were performed using the clinician-collected HPV tests as the comparator. The unweighted kappa statistic was used to evaluate the validity and reliability of self-collected HPV testing, and the level of agreement between the clinician-collected mRNA test and a DNA test that was used for routine care. A 13-question survey was used to assess acceptability. Results: Among the 70 participants, the median age was 50 years, 75% had an undetectable HIV RNA, and 11% had a CD4 count of <200 cells/μl. Nearly 63% had at least one positive HPV test. The sensitivity and specificity of the self-collected HPV test were 84.6% (95% confidence interval (CI) 65.1–95.6%) and 62.9% (95% CI 44.9–78.5%), respectively (κ = 0.5, 95% CI 0.2–0.7). The agreement between the two self-collected tests was good (κ = 0.8, 95% CI 0.5–1.0). There was good agreement between clinician-collected mRNA tests and DNA tests (κ = 0.8, 95% CI 0.7–1.0). Self-collection was highly acceptable. Conclusions: Among WLHIV, self-collected HPV tests had good sensitivity and moderate specificity compared to clinician-collected HPV tests. The reliability between self-collected testing locations was good. Self-collected HPV testing had high acceptability.

【 授权许可】

Unknown