The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting

Materials

Tae-Sik Jang¹  Hyoun-Ee Kim¹  Hyun Lee¹  Hyun-Do Jung²  Juha Song³ 

[1] Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Korea;;Liquid Processing &School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore;

关键词: freeze-casting;    porous materials;    porosity;    graded structure;    compressive strengths;   

DOI  :  10.3390/ma10040367

来源: DOAJ

【 摘 要 】

Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering.

【 授权许可】

Unknown