Critical Review on Fatty Acid-Based Food and Nutraceuticals as Supporting Therapy in Cancer

International Journal of Molecular Sciences

Sara Arranz¹  Itziar Tueros¹  Mercedes Caro Burgos¹  Javier Amézaga¹  Rosaria Ferreri²  Anna Sansone³  Chryssostomos Chatgilialoglu³  Carla Ferreri³ 

[1] AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio, Spain;Department of Integrated Medicine, Tuscany Reference Centre for Integrated Medicine in the Hospital Pathway, Pitigliano Hospital, ASL Sudest Toscana, 58017 Pitigliano, Italy;Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, Italy;

关键词: anticancer strategy;    fatty acid signaling;    membrane fatty acids;    membrane lipidomics;    dietary fatty acids;    precision nutraceuticals;   

DOI  :  10.3390/ijms23116030

来源: DOAJ

【 摘 要 】

Fatty acids have an important place in both biological and nutritional contexts and, from a clinical point of view, they have known consequences for diseases’ onset and development, including cancer. The use of fatty acid-based food and nutraceuticals to support cancer therapy is a multidisciplinary subject, involving molecular and clinical research. Knowledge regarding polyunsaturated fatty acids essentiality/oxidizability and the role of lipogenesis-desaturase pathways for cell growth, as well as oxidative reactivity in cancer cells, are discussed, since they can drive the choice of fatty acids using their multiple roles to support antitumoral drug activity. The central role of membrane fatty acid composition is highlighted for the application of membrane lipid therapy. As fatty acids are also known as biomarkers of cancer onset and progression, the personalization of the fatty acid-based therapy is also possible, taking into account other important factors such as formulation, bioavailability and the distribution of the supplementation. A holistic approach emerges combining nutra- and pharma-strategies in an appropriate manner, to develop further knowledge and applications in cancer therapy.

【 授权许可】

Unknown