Acute Hepatitis A Induction of Precursor B-Cell Acute Lymphoblastic Leukemia:A Causal Relationship

Case Reports in Oncology

关键词: Acute hepatitis A;    Precursor B-cell acute lymphoblastic leukemia;    Epstein-Barr virus;    Adult-onset ALL;    Hepatitis A-induced aplastic anemia;   

DOI  :  10.1159/000323487

来源: DOAJ

【 摘 要 】

Background: Precursor B-cell acute lymphoblastic leukemia accounts for 2% of all lymphoid neoplasms in the United States and occurs most frequently in childhood, but can also occur in adults with a median age of 39 years. It is more commonly seen in males and in Caucasians. Case Report: We present a case of a 51-year-old Caucasian female with the development of precursor B-cell acute lymphoblastic leukemia after suffering acute hepatitis A 4 weeks prior to her diagnosis. She presented with malaise for a month without spontaneous bruising/bleeding, infections, or B-symptoms, such as fevers, night sweats, or unintentional weight loss. Conclusion: Nonspecific viral transformation of bone marrow has been discussed in the literature, but we specifically describe hepatitis A-induced adult-onset precursor B-cell acute lymphoblastic leukemia, which is the first reported case in the literature.

【 授权许可】

Unknown