Psychiatric manifestations of sporadic Creutzfeldt-Jakob disease simulate depressive disorder with psychotic symptoms

European Journal of Case Reports in Internal Medicine

Joana Almeida Espírito Santo¹  Rui Garcia¹  Rui Marques dos Santos¹  Isabel Santana²  João Lemos² 

[1] Internal Medicine Department, University Hospital Center of Coimbra, Coimbra;Neurology Department, University Hospital Center of Coimbra, Coimbra;

关键词: Creutzfeldt–Jakob disease, sporadic Creutzfeldt–Jakob disease, depressive disorder with psychotic symptoms;   

DOI  :  10.12890/2015_000189

来源: DOAJ

【 摘 要 】

Creutzfeldt–Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a broad spectrum of early clinical manifestations, comprising neurological and psychiatric symptoms. The authors report the case of a patient admitted with a diagnosis of depressive disorder with psychotic symptoms, with post-mortem confirmation of CJD and discuss how CJD’s clinical heterogeneity can lead to misdiagnosis of the disease. Despite CJD’s unique pathogenesis, its kaleidoscopic presentation justifies the integrated investigation of patients with psychiatric symptoms, avoiding restrictive diagnosis.

【 授权许可】

Unknown