Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health

Giuseppe Lucisano¹  Giuseppe Di Martino²  Tommaso Staniscia²  Pamela Di Giovanni³  Ferdinando Romano⁴  Fabrizio Cedrone⁵  Francesca Meo⁵  Piera Scampoli⁵ 

[1] Centre for Outcomes Research and Clinical Epidemiology (CORESEARCH), Via Tiziano Veciello, 65100 Pescara, Italy;Department of Medicine and Aging Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy;Department of Pharmacy, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy;Department of Public Health and Infectious Diseases, “La Sapienza” University of Rome, P.zza Aldo Moro 5, 00100 Rome, Italy;School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy;

关键词: arsenic;    urothelial cancer;    meta-analysis;    drinking water;   

DOI  :  10.3390/ijerph17093105

来源: DOAJ

【 摘 要 】

Background: Arsenic is a toxic metalloid element widely distributed throughout the environment. Arsenic contaminated water has become an ongoing public health issue affecting hundred million people worldwide. The aim of this paper was to summarize the evidence in the association between arsenic metabolites and urinary tract cancer risk. Methods: A systematic review was conducted searching for observational studies that evaluated the association of arsenic metabolites and urinary tract cancer. Risk estimates from individual studies were pooled by using random effects models. Results: All the metabolites considered in this study resulted to be significantly associated to urothelial cancer, respectively: IA% 3.51 (1.21–5.82) (p = 0.003), MMA with WMD = 2.77 (1.67–3.87) (p < 0.001) and DMA with WMD = −4.56 (−7.91–1.22) (p = 0.008). Conclusions: Arsenic metabolites are significantly associated to urothelial cancer. Future studies will help to verify the independent association(s) between arsenic metabolites and urothelial cancer.

【 授权许可】

Unknown