Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Marilia A. Correia¹  Pedro Puech‐Leao²  Lauro C. Vianna³  Breno Q. Farah⁴  Paulo L. Oliveira⁵  Raphael M. Ritti‐Dias⁵  Gabriel G. Cucato⁶  Nelson Wolosker⁶  Daniel J. Green⁷ 

[1] Associated Graduated Program in Physical Education Universidade de Pernambuco e Universidade da Paraíba Recife Brazil;Faculty of Medicine University of São Paulo Brazil;Faculty of Physical Education Universidade de Brasília Brasília Brazil;Federal Rural University of Pernambuco Recife Brazil;Graduated Program in Rehabilitation Sciences Universidade Nove de Julho São Paulo Brazil;Hospital Israelita Albert Einstein São Paulo Brazil;The University of Western Australia Perth Australia;

关键词: blood pressure;    cardiovascular system;    intermittent claudication;    peripheral vascular disease;   

DOI  :  10.1161/JAHA.119.013596

来源: DOAJ

【 摘 要 】

Background Meta‐analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease. Methods and Results A randomized controlled trial with peripheral artery disease patients assigned to either the IHT or control group was conducted. The IHT group performed 3 sessions per week, for 8 weeks, of unilateral handgrip exercises, consisting of 4 sets of isometric contractions for 2 minutes at 30% of maximum voluntary contraction and a 4‐minute interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. The primary outcome was brachial BP. The secondary outcomes were central BP, arterial stiffness parameters, cardiac autonomic modulation, and vascular function. The IHT program reduced diastolic BP (75 [10] mm Hg preintervention versus 72 [11] mm Hg postintervention), with no change in the control group (74 [11] mm Hg preintervention versus 74 [11] mm Hg postintervention), with this between‐group difference being significant (P=0.04). Flow‐mediated dilation improved in the IHT group (6.0% [5.7] preintervention versus 9.7% [5.5] postintervention), with no change in the control group (7.6% [5.5] preintervention versus 7.4% [5.1] postintervention), with this between‐group difference being significant (P=0.04). There was no change in other measured variables over the intervention period. Conclusions IHT reduced brachial diastolic BP and improved local vascular function in patients with peripheral artery disease. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02742220.

【 授权许可】

Unknown