Associations between Chest CT Abnormalities and Clinical Features in Patients with the Severe Fever with Thrombocytopenia Syndrome

Viruses

Shimpei Morimoto¹  Konosuke Morimoto²  Koya Ariyoshi²  Shungo Katoh³  Masato Tashiro⁴  Koichi Izumikawa⁴  Takeshi Tanaka⁴  Katzunori Yanagihara⁵  Shintaro Kurihara⁶  Makoto Sumiyoshi⁷  Shotaro Ide⁷  Hiroshi Mukae⁸  Hiroki Ashizawa⁸  Nobuyuki Ashizawa⁹  Noriho Sakamoto⁹  Kazuaki Takeda⁹  Takahiro Takazono⁹  Kazuko Yamamoto⁹  Naoki Iwanaga⁹  Tsutomu Kobayashi^1,10  Masataka Yoshida^1,11  Yuichi Fukuda^1,11  Asuka Umemura^1,11  Kouichi Morita^1,12  Shingo Inoue^1,12  Mya Myat Ngwe Tun^1,12 

[1] Clinical Research Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan;Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan;Department of General Internal Medicine, Nagasaki Rosai Hospital, Nagasaki 857-0134, Japan;Department of Infection Control and Education Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan;Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan;Department of Medical Safety, Nagasaki University Hospital, Nagasaki 852-8102, Japan;Department of Respiratory Medicine, Isahaya General Hospital, Isahaya 854-8501, Japan;Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, Japan;Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan;Department of Respiratory Medicine, Sasebo Chuo Hospital, Sasebo 857-1195, Japan;Department of Respiratory Medicine, Sasebo City General Hospital, Sasebo 857-8511, Japan;Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan;

关键词: severe fever with thrombocytopenia syndrome;    lung abnormalities;    chest computed tomography;    ground-glass opacity;   

DOI  :  10.3390/v14020279

来源: DOAJ

【 摘 要 】

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus. It involves multiple organ systems, including the lungs. However, the significance of the lung involvement in SFTS remains unclear. In the present study, we aimed to investigate the relationship between the clinical findings and abnormalities noted in the chest computed tomography (CT) of patients with SFTS. The medical records of 22 confirmed SFTS patients hospitalized in five hospitals in Nagasaki, Japan, between April 2013 and September 2019, were reviewed retrospectively. Interstitial septal thickening and ground-glass opacity (GGO) were the most common findings in 15 (68.1%) and 12 (54.5%) patients, respectively, and lung GGOs were associated with fatalities. The SFTS patients with a GGO pattern were elderly, had a disturbance of the conscious and tachycardia, and had higher c-reactive protein levels at admission (p = 0.009, 0.006, 0.002, and 0.038, respectively). These results suggested that the GGO pattern in patients with SFTS displayed disseminated inflammation in multiple organs and that cardiac stress was linked to higher mortality. Chest CT evaluations may be useful for hospitalized patients with SFTS to predict their severity and as early triage for the need of intensive care.

【 授权许可】

Unknown