Risk Factors Associated with Recurrent Clostridioides difficile Infection

Healthcare

Marius Rus¹  Tapan Behl²  Simona Bungau³  DeliaMirela Tit³  Cristiana Bustea⁴  CosminMihai Vesa⁴  Flavia-Maria Pavel⁴  Nicoleta Negrut⁵  DeliaCarmen Nistor-Cseppento⁵  ShamimAhmad Khan⁶ 

[1] Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India;Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 N. Jiga St., 410028 Oradea, Romania;Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania;Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;

关键词: Clostridioides difficile;    recurrent disease;    risk factors;    antibiotic-associated diarrhea;    ATLAS score;    Charlson Comorbidity Index;   

DOI  :  10.3390/healthcare8030352

来源: DOAJ

【 摘 要 】

Clostridioides difficile (CD) is responsible for nosocomial diarrhea syndrome with possible severe progression. Recurrence of the disease induces higher health system costs, as well as exposes patients to additional health risks. Patients with recurrence of this disease are difficult to identify, so the purpose of this study is to quantify various demographic, clinical, and treatment factors that could prevent further progression to recurrence of the disease. In the period 2018–2019, about 195 patients were diagnosed with more than one episode of CDI in the three months following the first episode. The recurrence rate for CDI was 53.84% (60.95% for one episode and 39.05% for multiple episodes). Most commonly afflicted were 60–69-year-old patients, or those with higher Charlson Comorbidity Index (CCI). Multiple analyses associated cardiovascular (odds ratios (OR) = 3.02, 95% confidence intervals (CI) = 1.23–7.39, p = 0.015), digestive (OR = 3.58, 95% CI = 1.01–12.63, p = 0.047), dementia (OR = 3.26, 95% CI = 1.26–8.41, p = 0.014), immunosuppressive (OR = 3.88, 95% CI = 1.34–11.21, p = 0.012) comorbidities with recurrences. Risk factor identification in the first episode of CDI could lead to the implementation of treatment strategies to improve the patients’ quality of life affected by this disease.

【 授权许可】

Unknown