Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons

Molecular Brain

Seon-Heui Cha¹  Yu Ree Choi¹  Sang Myun Park¹  Tae-Young Ha¹  Hye Rin Noh¹  Jae-Bong Kim¹ 

[1] Department of Pharmacology, Ajou University School of Medicine;

关键词: Parkinson’s disease;    α-synuclein;    Cell-to-cell transmission;    Endocytosis;    Caveolin-1;    Aging;   

DOI  :  10.1186/s13041-021-00834-2

来源: DOAJ

【 摘 要 】

Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded α-synuclein (α-syn) released from neurons to neighboring neurons plays an important role in PD progression. In the present study, we demonstrated that cav-1 expression in the brain increased with age, and considerably increased in the brain of A53T α-syn transgenic mice. Cav-1 overexpression facilitated the uptake of α-syn into neurons and formation of additional Lewy body-like inclusion bodies, phosphorylation of cav-1 at tyrosine 14 was found to be crucial for this process. This study demonstrates the relationship between age and α-syn spread and will facilitate our understanding of the molecular mechanism of the cell-to-cell transmission of α-syn.

【 授权许可】

Unknown