Curcumin (a constituent of turmeric): New treatment option against COVID‐19

Food Science & Nutrition

Fatemeh Babaei¹  Hossein Hosseinzadeh²  Marjan Nassiri‐Asl³ 

[1] Department of Clinical Biochemistry School of Medicine, Student Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran;Department of Pharmacodynamics and Toxicology School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran;Department of Pharmacology and Neurobiology Research Center School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran;

关键词: antiapoptotic;    antifatigue;    antifibrotic;    anti‐inflammatory;    antiviral;    Coronavirus‐19;   

DOI  :  10.1002/fsn3.1858

来源: DOAJ

【 摘 要 】

Abstract In late December 2019, the outbreak of respiratory illness emerged in Wuhan, China, and spreads worldwide. World Health Organization (WHO) named this disease severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused by a new member of beta coronaviruses. Several medications are prescribed to patients, and some clinical trials are underway. Scientists are trying to find a specific drug against this virus. In this review, we summarize the pathogenesis, clinical features, and current treatments of coronavirus disease 2019 (COVID‐19). Then, we describe the possible therapeutic effects of curcumin and its molecular mechanism against coronavirus‐19. Curcumin, as an active constituent of Curcuma longa (turmeric), has been studied in several experimental and clinical trial studies. Curcumin has some useful clinical effects such as antiviral, antinociceptive, anti‐inflammatory, antipyretic, and antifatigue effects that could be effective to manage the symptoms of the infected patient with COVID‐19. It has several molecular mechanisms including antioxidant, antiapoptotic, and antifibrotic properties with inhibitory effects on Toll‐like receptors, NF‐κB, inflammatory cytokines and chemokines, and bradykinin. Scientific evidence suggests that curcumin could have a potential role to treat COVID‐19. Thus, the use of curcumin in the clinical trial, as a new treatment option, should be considered.

【 授权许可】

Unknown