Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis

Journal of Personalized Medicine

Viorel Ţarcă¹  Valentin Munteanu²  Elena Cojocaru³  Lăcrămioara Ionela Butnariu⁴  Ștefana Maria Moisă⁵  Valeriu Vasile Lupu⁵  Laura Trandafir⁵  Alina Costina Luca⁵  Solange Tamara Roșu⁶  Elena Ţarcă⁷ 

[1] County Statistics Department, 700115 Iaşi, Romania;Department of Biomedical Sciences, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania;Department of Morphofunctional Sciences I—Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania;Department of Mother and Child Medicine—Genetics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania;Department of Mother and Child Medicine—Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania;Department of Nursing, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania;Department of Surgery II—Pediatric Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania;

关键词: gastroschisis;    morbidity;    mortality;    outcome;   

DOI  :  10.3390/jpm11111168

来源: DOAJ

【 摘 要 】

Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome.

【 授权许可】

Unknown