Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

International Journal of Molecular Sciences

Peir-Haur Hung¹  Tsung-Hsien Chen¹  Chun-Liang Lin²  Yung-Chien Hsu² 

[1] Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600566, Taiwan;Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan;

关键词: diabetic kidney disease;    inflammation;    albuminuria;    fibrosis;    glomerulosclerosis;   

DOI  :  10.3390/ijms222111857

来源: DOAJ

【 摘 要 】

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.

【 授权许可】

Unknown