Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis

Frontiers in Molecular Biosciences

Rong Hu²  Yuze Liu²  Dehui Xiong²  Kearabetsoe Matseliso Molibeli²  Lijun Tang² 

[1] School of Life Science, Central South University, Changsha, China;Xiangya School of Medicine, Central South University, Changsha, China;

关键词: exosomes;    exosomal circRNA;    biomarker;    miRNA sponge;    diagnosis;    therapeutic target;   

DOI  :  10.3389/fmolb.2021.769832

来源: DOAJ

【 摘 要 】

Exosomes are small vesicles derived from cells used as cell-to-cell communication goods in numerous diseases including tumorigenesis, neurological diseases, cardiovascular diseases and other diseases. Circular RNAs (circRNAs) are an innovative constituent of non-coding endogenous RNAs generated through backsplicing, catalyzed by RNA polymerase Ⅱ. These non-coding RNAs have been suggested to control gene expression through miRNA sponging, RNA-binding protein regulation and translational capabilities. Genome-wide RNA sequence analyses observed that circRNAs were stably improved in exosomes in association to parental cells. Little attention has been dedicated to exosomal circRNAs (exo-circRNAs). However, research has demonstrated that exo-circRNAs may have important regulatory functions because of their stability in cells and within exosomes. If well understood, the precise roles and mechanisms of exo-circRNAs might surge the impending clinical applications of these molecules as markers in the identification, prediction and treatment of various diseases. In this review, we outline recent findings regarding exo-circRNAs which includes their functions and highlights their potential applications and therapeutic targets in human diseases.

【 授权许可】

Unknown