An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens

International Journal of Molecular Sciences

NebojsaNick Knezevic¹  KennethD. Candido¹  Stephania Paredes¹  Santiago Cantillo¹ 

[1] Department of Anesthesiology, Advocate Illinois Masonic Medical Center, 836 W. Wellington Ave. Suite 4815, Chicago, IL 60657, USA;

关键词: serotonin;    ovarian steroids;    pain disorders;    hormones;    irritable bowel syndrome;    migraine;    headache;    fibromyalgia;    chronic fatigue syndrome;   

DOI  :  10.3390/ijms20225729

来源: DOAJ

【 摘 要 】

Ovarian hormones play an important role in pain perception, and are responsible, at least in part, for the pain threshold differences between the sexes. Modulation of pain and its perception are mediated by neurochemical changes in several pathways, affecting both the central and peripheral nervous systems. One of the most studied neurotransmitters related to pain disorders is serotonin. Estrogen can modify serotonin synthesis and metabolism, promoting a general increase in its tonic effects. Studies evaluating the relationship between serotonin and disorders such as irritable bowel syndrome, fibromyalgia, migraine, and other types of headache suggest a clear impact of this neurotransmitter, thereby increasing the interest in serotonin as a possible future therapeutic target. This literature review describes the importance of substances such as serotonin and ovarian hormones in pain perception and illustrates the relationship between those two, and their direct influence on the presentation of the aforementioned pain-related conditions. Additionally, we review the pathways and receptors implicated in each disorder. Finally, the objective was to stimulate future pharmacological research to experimentally evaluate the potential of serotonin modulators and ovarian hormones as therapeutic agents to regulate pain in specific subpopulations.

【 授权许可】

Unknown