Glutathione and Nitric Oxide: Key Team Players in Use and Disuse of Skeletal Muscle

Nutrients

Fabio Ciccarone¹  Sara Baldelli¹  Paola Checconi¹  Dolores Limongi¹  MariaRosa Ciriolo²  AnnaTeresa Palamara² 

[1] IRCCS San Raffaele Pisana, Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy;IRCCS San Raffaele ‘La Pisana’, 00166 Rome, Italy;

关键词: atrophy;    exercise;    oxidative stress;    nitrosative stress;    inflammation;   

DOI  :  10.3390/nu11102318

来源: DOAJ

【 摘 要 】

Glutathione (GSH) is the main non-enzymatic antioxidant playing an important role in detoxification, signal transduction by modulation of protein thiols redox status and direct scavenging of radicals. The latter function is not only performed against reactive oxygen species (ROS) but GSH also has a fundamental role in buffering nitric oxide (NO), a physiologically-produced molecule having-multifaceted functions. The efficient rate of GSH synthesis and high levels of GSH-dependent enzymes are characteristic features of healthy skeletal muscle where, besides the canonical functions, it is also involved in muscle contraction regulation. Moreover, NO production in skeletal muscle is a direct consequence of contractile activity and influences several metabolic myocyte pathways under both physiological and pathological conditions. In this review, we will consider the homeostasis and intersection of GSH with NO and then we will restrict the discussion on their role in processes related to skeletal muscle function and degeneration.

【 授权许可】

Unknown