Implementing Silicon Nanoribbon Field-Effect Transistors as Arrays for Multiple Ion Detection

Biosensors

Steffen Müller¹  Iain A. Wright¹  Edwin C. Constable¹  Colin J. Martin¹  Michel Calame²  Ralph L. Stoop²  Axel Fanget²  Mathias Wipf²  Christian Schönenberger²  Kristine Bedner³ 

[1] Department of Chemistry, University of Basel, Basel 4056, Switzerland;Department of Physics, University of Basel, Basel 4056, Switzerland;Laboratory for Micro- and Nanotechnology, Paul Scherrer Institute, Villigen 5232, Switzerland;

关键词: chemical sensing;    nanoribbons;    sodium;    fluoride;    gold;    ion-sensitive field-effect transistors;    chemFETs;   

DOI  :  10.3390/bios6020021

来源: DOAJ

【 摘 要 】

Ionic gradients play a crucial role in the physiology of the human body, ranging from metabolism in cells to muscle contractions or brain activities. To monitor these ions, inexpensive, label-free chemical sensing devices are needed. Field-effect transistors (FETs) based on silicon (Si) nanowires or nanoribbons (NRs) have a great potential as future biochemical sensors as they allow for the integration in microscopic devices at low production costs. Integrating NRs in dense arrays on a single chip expands the field of applications to implantable electrodes or multifunctional chemical sensing platforms. Ideally, such a platform is capable of detecting numerous species in a complex analyte. Here, we demonstrate the basis for simultaneous sodium and fluoride ion detection with a single sensor chip consisting of arrays of gold-coated SiNR FETs. A microfluidic system with individual channels allows modifying the NR surfaces with self-assembled monolayers of two types of ion receptors sensitive to sodium and fluoride ions. The functionalization procedure results in a differential setup having active fluoride- and sodium-sensitive NRs together with bare gold control NRs on the same chip. Comparing functionalized NRs with control NRs allows the compensation of non-specific contributions from changes in the background electrolyte concentration and reveals the response to the targeted species.

【 授权许可】

Unknown