Emerging functional similarities and divergences between Drosophila Spargel /dPGC-1 and mammalian PGC-1 protein

Frontiers in Genetics

Subhas eMukherjee¹  Claudette eDavis²  Mohammed Abdul Basar³  Atanu eDuttaroy³ 

[1] Emory University;George Mason University;Howard University;

关键词: Drosophila;    Mitochondria;    Oogenesis;    PGC-1;    RNA processing;   

DOI  :  10.3389/fgene.2014.00216

来源: DOAJ

【 摘 要 】

Peroxisome Proliferator Activated Receptor Gamma Co-activator-1 (PGC-1) is a well- conserved protein among all chordates.Entire Drosophila species subgroup carries a PGC-1 homolog in their genome called spargel/dPGC-1 showing very little divergence.Recent studies have reported that significant functional similarities are shared between vertebrate and invertebrate PGC-1’s based on their role in mitochondrial functions and biogenesis, gluconeogenesis, and most likely in transcription and RNA processing.With the help of genetic epistasis analysis, we established that Drosophila Spargel/dPGC-1 affects cell growth process as a terminal effector in the Insulin-TOR signaling pathway. The association between Spargel and Insulin signaling could also explain its role in the aging process. Here we provided a further comparison between Spargel/dPGC-1 and PGC-1 focusing on nuclear localization, oxidative stress resistance and a possible role of Spargel/dPGC-1 in oogenesis reminiscing the role of Spargel in reproductive aging like many Insulin signaling partners.This led us to hypothesize that the discovery of newer biological functions in Drosophila Spargel/dPGC-1 will pave the way to uncover novel functional equivalents in mammals.

【 授权许可】

Unknown