Regenerative frontiers in craniofacial reconstruction: Grand challenges and opportunities for the mammalian transforming growth factor-β proteins

Frontiers in Physiology

Roland Manfred Klar¹  Ugo eRipamonti¹ 

[1] Medical Research Council/University of the Witwatersrand, Johannesburg;

关键词: Bone Morphogenetic Proteins;    Regenerative Medicine;    Tissue Engineering;    osteogenic proteins;    craniofacial surgery;    dissociative extraction and reconstitution;   

DOI  :  10.3389/fphys.2010.00143

来源: DOAJ

【 摘 要 】

Science’s fascination with bone and its repair processes span for thousands of years since the ancient Greek Hippocrates, the father of Medicine, made the key discovery that bone heals without scarring. Through the centuries, several lucid investigators perceived that the extracellular matrix of bone must be a reservoir of differentiating and morphogenetic factors ultimately responsible for its pronounced healing potential (reviewed in Urist 1968; Urist 1994; Reddi 2000; Ripamonti et al. 2006).

【 授权许可】

Unknown