Improved bioaccessibility of polymethoxyflavones loaded into high internal phase emulsions stabilized by biopolymeric complexes: A dynamic digestion study via TNO's gastrointestinal model

Current Research in Food Science

Huijuan Zheng¹  Qingrong Huang¹  Ting Zheng²  Shiwei Su²  Ashok R. Patel²  Paul Van der Meeren³  Wahyu Wijaya⁴ 

[1] Corresponding author.;Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ, 08901, USA;Guangdong Technion Israel Institute of Technology, 241 Daxue Road, Shantou, 515063, China;Particle and Interfacial Technology Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000, Gent, Belgium;

关键词: Polymethoxyflavones;    Tangeretin;    Nobiletin;    High internal phase emulsion;    Complexes;    Bioaccessibility;   

DOI  :  

来源: DOAJ

【 摘 要 】

In this work, the bioaccessibility of polymethoxyflavones (PMFs) loaded in high internal phase emulsions (HIPE, ϕoil = 0.82) stabilized by whey protein isolate (WPI)-low methoxy pectin (LMP) complexes was evaluated using in vitro lipolysis and dynamic in vitro intestinal digestion studies. PMFs loaded HIPE was prepared by using aqueous dispersion of pre-formed biopolymeric complexes (WPI-LMP, 2:1 ratio) as the external phase and medium chain triglycerides oil (containing PMFs extracted from citrus peel) as the dispersed phase. The in vitro lipolysis study revealed that PMFs in HIPE became bioaccessible much higher than PMFs in medium chain triacylglycerols oil (MCT oil). In addition, by simulating the entire human gastrointestinal (GI) tract, the GI model TIM-1 demonstrated a 5- and 2-fold increase in the total bioaccessibility for two major PMFs encapsulated in HIPE, i.e. tangeretin (TAN) and nobiletin (NOB), respectively, as opposed to PMFs in MCT oil. Together these results from the digestion study showed that the incorporation of a high amount of PMFs into the viscoelastic matrix of HIPE could represent an innovative and effective way to design an oral delivery system. Such a system could be used to control and to improve the delivery of lipophilic bioactive compounds within the different compartments of the digestive tract, especially the human upper GI tract.

【 授权许可】

Unknown