Effects of troxerutin on anxiety- and depressive-like behaviors induced by chronic mild stress in adult male rats

Iranian Journal of Basic Medical Sciences

Shirin Babri¹  Maryam Azarfarin²  Gisou Mohaddes³  Fereshteh Farajdokht⁴  Milad Taghizadeh⁴  Farzad Salehpour⁴ 

[1] Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

[2] Higher Education Institute of Rab-Rashid, Tabriz, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

[3] Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran;Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: anxiety;    Chronic mild stress;    cortisol;    depression;    Troxerutin;   

DOI  :  10.22038/ijbms.2018.26915.6582

来源: DOAJ

【 摘 要 】

Objective(s):Chronic stress has been linked to the pathophysiology of mood disorders including anxiety and depression. In this study, we aimed to investigate the effect of troxerutin (TRX), as a flavonol, on stress-induced anxiety and depression.Materials and Methods: 56 animals were randomly divided into seven groups (n=8 per group) as follows: control, saline, TRX 50, TRX 150, TRX 300, Diazepam, and Imipramine. Chronic mild stress (CMS) was induced by restraining animals in Plexiglas cylinders for 1 hr each day for 25 consecutive days. Different doses (50, 150, and 300 mg/kg, oral gavage) of troxerutin was gavaged for 14 consecutive days. At the end of treatments, anxiety- and depressive-like behaviors were tested using elevated plus-maze (EPM), open field test (OFT), and forced swimming test (FST). Results: CMS significantly increased immobility (P

【 授权许可】

Unknown