Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Christoph Knappich¹  Sofie Schmid¹  Hans‐Henning Eckstein¹  Andreas Kuehnl¹  Pavlos Tsantilas¹  Alexander Zimmermann¹  Michael Kallmayer¹  Thorben Breitkreuz² 

[1] Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany;aQua—Institute for Applied Quality Improvement and Research in Health GmbH, Göttingen, Germany;

关键词: amaurosis fugax;    carotid stenosis;    carotid stenting;    cohort;    nationwide;    peri‐interventional outcome;   

DOI  :  10.1161/JAHA.117.007983

来源: DOAJ

【 摘 要 】

BackgroundSubgroup analyses from randomized trials indicate that the time interval between the neurologic index event and carotid artery stenting is associated with periprocedural stroke and death rates in patients with symptomatic carotid stenosis. The aim of this article is to analyze whether this observation holds true under routine conditions in Germany. Methods and ResultsSecondary data analysis was done on 4717 elective carotid artery stenting procedures that were performed for symptomatic carotid stenosis. The patient cohort was divided into 4 groups according to the time interval between the index event and intervention (group I 0‐2, II 3‐7, III 8‐14, and IV 15‐180 days). Primary outcome was any in‐hospital stroke or death. For risk‐adjusted analyses, a multilevel multivariable regression model was used. The in‐hospital stroke or death rate was 3.7% in total and 6.0%, 4.4%, 2.4%, and 3.0% in groups I, II, III, and IV, respectively. Adjusted analysis showed a decreased risk for any stroke or death in group III, a decreased risk for any major stroke or death in groups III and IV, and a decreased risk for any death in groups II and III compared to the reference group I. ConclusionsA short time interval between the neurologic index event and carotid artery stenting of up to 7 days is associated with an increased risk for stroke or death under routine conditions in Germany. Although results cannot prove causal relationships, carotid artery stenting may be accompanied by an increased risk of stroke or death during the early period after the index event.

【 授权许可】

Unknown