The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications

AMB Express

Mengmeng Jin¹  Liying Zhu²  Anqi Xiao²  Ling Jiang³  He Huang⁴  Zhidong Zhang⁵ 

[1]College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University

[2]College of Chemical and Molecular Engineering, Nanjing Tech University

[3]College of Food Science and Light Industry, Nanjing Tech University

[4]College of Pharmaceutical Science, Nanjing Tech University

[5]Institute of Microbiology, Xinjiang Academy of Agricultural Sciences

关键词: Deinococcus;    Ionizing radiation;    DNA repair;    Anti-oxidation;   

DOI  :  10.1186/s13568-019-0862-x

来源: DOAJ

【 摘 要 】

Abstract Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection mechanisms of Deinococcus depend on a combination of passive and active defense mechanisms, including self-repair of DNA damage (homologous recombination, MMR, ER and ESDSA), efficient cellular damage clearance mechanisms (hydrolysis of damaged proteins, overexpression of repair proteins, etc.), and effective clearance of reactive oxygen species (ROS). Due to these mechanisms, Deinococcus cells are highly resistant to oxidation, radiation and desiccation, which makes them potential chassis cells for wide applications in many fields. This article summarizes the latest research on the radiation-resistance mechanisms of Deinococcus and prospects its biotechnological application potentials.

【 授权许可】

Unknown