Staphylococcal Enterotoxin C—An Update on SEC Variants, Their Structure and Properties, and Their Role in Foodborne Intoxications

Toxins

Jenny Schelin¹  Danai Etter²  Sophia Johler²  Markus Schuppler³ 

[1] Division of Applied Microbiology, Department of Chemistry, Lund University, 22100 Lund, Sweden;Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zürich, 8057 Zürich, Switzerland;Laboratory of Food Microbiology, Institute of Food, Nutrition and Health, ETH Zürich, 8092 Zürich, Switzerland;

关键词: staphylococcal food poisoning;    SEC;    superantigen;    emesis;    host specificity;   

DOI  :  10.3390/toxins12090584

来源: DOAJ

【 摘 要 】

Staphylococcal enterotoxins are the most common cause of foodborne intoxications (staphylococcal food poisoning) and cause a wide range of diseases. With at least six variants staphylococcal enterotoxin C (SEC) stands out as particularly diverse amongst the 25 known staphylococcal enterotoxins. Some variants present unique and even host-specific features. Here, we review the role of SEC in human and animal health with a particular focus on its role as a causative agent for foodborne intoxications. We highlight structural features unique to SEC and its variants, particularly, the emetic and superantigen activity, as well as the roles of SEC in mastitis and in dairy products. Information about the genetic organization as well as regulatory mechanisms including the accessory gene regulator and food-related stressors are provided.

【 授权许可】

Unknown