Survival Factors and Metabolic Pathogenesis in Elderly Patients (≥65) With COVID-19: A Multi-Center Study

Frontiers in Medicine

Jian Li¹  Christian Kurts¹  Patrick Wu²  Ke Ma³  Liang Wu⁴  Huawen Chen⁴  Jinlong Luo⁴  Yong Li⁵  Amy Bryant⁷  Fei Wang⁸  Amanda Y. Wang⁹  Ming Li^1,10  Shangming Du^1,11  Yang Yang^1,12  Qi Mei^1,14  Xianglin Yuan^1,14  Guangyuan Hu^1,14 

[1] 0Institute of Experimental Immunology, University Clinic of Rheinische Friedrich-Wilhelms-University, Bonn, Germany;1Department of Anaesthesiology, Queen Mary Hospital, Hong Kong, China;2Department and Institute of Infectious Disease, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;3Department of Emergency Medicine, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;4Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;Concord Clinical School, The University of Sydney, Newtown, NSW, Australia;Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Meridian, ID, United States;Department of Chinese Medicine, Tongji Medical College, Wuhan No. 1 Hospital, Huazhong University of Science and Technology, Wuhan, China;Department of Renal Medicine, Concord Repatriation General Hospital, Newtown, NSW, Australia;Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China;Ludwig Maximilian University of Munich, Munich, Germany;Renmin Hospital of Wuhan University, Wuhan, China;The Renal and Metabolic Division, The George Institute for Global Health, University of New South Wales, Newtown, NSW, Australia;Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;

关键词: clinical stratification;    elderly patients;    mortality;    prognostic factors;    COVID-19;    metabolic pathogenesis;   

DOI  :  10.3389/fmed.2020.595503

来源: DOAJ

【 摘 要 】

Background: Elderly patients infected with COVID-19 are reported to be facing a substantially increased risk of mortality. Clinical characteristics, treatment options, and potential survival factors remain under investigation. This study aimed to fill this gap and provide clinically relevant factors associated with survival of elderly patients with COVID-19.Methods: In this multi-center study, elderly patients (age ≥65 years old) with laboratory-confirmed COVID-19 from 4 Wuhan hospitals were included. The clinical end point was hospital discharge or deceased with last date of follow-up on Jul. 08, 2020. Clinical, demographic, and laboratory data were collected. Univariate and multivariate analysis were performed to analyze survival and risk factors. A metabolic flux analysis using a large-scale molecular model was applied to investigate the pathogenesis of SARS-CoV-2 with regard to metabolism pathways.Results: A total of 223 elderly patients infected with COVID-19 were included, 91 (40.8%) were discharged and 132 (59.2%) deceased. Acute respiratory distress syndrome (ARDS) developed in 140 (62.8%) patients, 23 (25.3%) of these patients survived. Multivariate analysis showed that potential risk factors for mortality were elevated D-Dimer (odds ratio: 1.13 [95% CI 1.04 - 1.22], p = 0.005), high immune-related metabolic index (6.42 [95% CI 2.66–15.48], p < 0.001), and increased neutrophil-to-lymphocyte ratio (1.08 [95% 1.03–1.13], p < 0.001). Elderly patients receiving interferon atmotherapy showed an increased probability of survival (0.29 [95% CI 0.17–0.51], p < 0.001). Based on these factors, an algorithm (AlgSurv) was developed to predict survival for elderly patients. The metabolic flux analysis showed that 12 metabolic pathways including phenylalanine (odds ratio: 28.27 [95% CI 10.56–75.72], p < 0.001), fatty acid (15.61 [95% CI 6.66–36.6], p < 0.001), and pyruvate (12.86 [95% CI 5.85–28.28], p < 0.001) showed a consistently lower flux in the survivors vs. the deceased subgroup. This may reflect a key pathogenic mechanism of COVID-19 infection.Conclusion: Several factors such as interferon atmotherapy and recreased activity of specific metabolic pathways were found to be associated with survival of elderly patients. Based on these findings, a survival algorithm (AlgSurv) was developed to assist the clinical stratification for elderly patients. Dysregulation of the metabolic pathways revealed in this study may aid in the drug and vaccine development against COVID-19.

【 授权许可】

Unknown