Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis

BMC Gastroenterology

Mark M. Aloysius¹  Niraj James Shah²  Shou-Jiang Tang²  Savio John³  Ganesh Aswath⁴  Shweta Gupta⁵  Eldrin Bhanat⁶  Hemant Goyal⁷ 

[1]Department of Internal Medicine, The Wright Center for Graduate Medical Education

[2]Department of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center

[3]Division Chief Gastroenterology, Upstate University Hospital

[4]Division of Gastroenterology, Upstate University Hospital

[5]Division of Hematology-Oncology, Jr Hospital of Cook County

[6]Mississippi Colorectal Cancer Roundtable, University of Mississippi Medical Center

[7]The Wright Center for Graduate Medical Education

关键词: Primary mucosal melanoma;    Gastrointestinal mucosal melanoma;    Survival outcomes;    Surgery;    Chemotherapy;    Radiation therapy;   

DOI  :  10.1186/s12876-022-02254-5

来源: DOAJ

【 摘 要 】

Abstract Aim Gastrointestinal malignant melanoma is a rare mucosal melanoma (MM). Other MM include the respiratory and the genitourinary tract. All mucosal melanomas have a poor prognosis when compared to cutaneous melanomas. Ano-rectal melanomas are by far the most common and most studied gastrointestinal MM. Large-scale clinical data is lacking due to the rarity of the disease. We aim to analyze epidemiology and survival of the Gastrointestinal (G.I.) MM over 45 years using a national database. Methods The Surveillance, Epidemiology and End Results (SEER) database was queried to identify patients with biopsy-proven G.I. Melanomas. We selected tumor site, intervention, and survival information for oncology codes as per the international classification of diseases. Survival analysis was performed using the SPSS v 27 ® IBM software. Results Of the 1105 biopsy-proven confirmed cases of primary G.I. melanoma's, 191 (17.3%) received chemotherapy (C.T.), 202 (18.3%) received radiotherapy (R.T.), 63 (5.7%) received both C.T and R.T., while 684 (61.9%) of the population received surgery alone or combined with C.T. and/or R.T. Statistically significant improvement in survival was noted in all treatment strategies that utilized surgery and also when site-specific MM cohorts underwent a surgical approach with or without C.T and/or R.T. Conclusion This is the most extensive study reporting epidemiological and survival data of treatment strategy outcomes of primary G.I. mucosal melanoma elucidating best overall survival with a management strategy involving surgical intervention.

【 授权许可】

Unknown